No effect (false positives), 6 + 6 dams: A pups as n 43.7%; B litter means 4.2%; C litter means adjusted for litter size 4.7%; E one pup per litter 4.4% Treated pups 1 g lighter (power), 6 + 6 dams: A pups as n 82.0%; B litter means 35.3%; C litter means adjusted for litter size 42.8%; E one pup per litter 26.9% No effect (false positives), 12 + 12 dams: A pups as n 40.5%; B litter means 4.3%; C litter means adjusted for litter size 4.4%; E one pup per litter 4.3% Treated pups 1 g lighter (power), 12 + 12 dams: A pups as n 94.6%; B litter means 67.1%; C litter means adjusted for litter size 78.1%; E one pup per litter 52.5%