12 litters, 71 pups genotyped at weaning
observed wild-type 17, heterozygous 40, knockout 14; expected 17.75, 35.50, 17.75
A. Chi-square goodness of fit to 1:2:1: chi2(2) = 1.39, p = 0.5
B. Exact multinomial test of 1:2:1: p = 0.54
C. Exact binomial test, knockouts against 1/4 of pups: 14 of 71 (19.7%), p = 0.34
D. Knockout viability relative to wild-type littermates: 0.82 (exact 95% CI 0.38 to 1.78), p = 0.72
Sex ratio: 38 females of 71, exact binomial p = 0.64