No lethality (false positives), 6 litters (mean 43 pups): A chi-square 1:2:1 4.8%; C binomial knockouts vs 1/4 3.8%; D knockouts vs wild-type 2.9%
No lethality (false positives), 12 litters (mean 85 pups): A chi-square 1:2:1 5.0%; C binomial knockouts vs 1/4 4.2%; D knockouts vs wild-type 3.5%
No lethality (false positives), 24 litters (mean 171 pups): A chi-square 1:2:1 5.2%; C binomial knockouts vs 1/4 4.5%; D knockouts vs wild-type 4.0%
No lethality (false positives), 48 litters (mean 342 pups): A chi-square 1:2:1 5.1%; C binomial knockouts vs 1/4 5.1%; D knockouts vs wild-type 4.3%
Knockouts survive at 75%, 6 litters (mean 40 pups): A chi-square 1:2:1 8.1%; C binomial knockouts vs 1/4 7.3%; D knockouts vs wild-type 7.0%
Knockouts survive at 75%, 12 litters (mean 80 pups): A chi-square 1:2:1 12.2%; C binomial knockouts vs 1/4 14.2%; D knockouts vs wild-type 10.8%
Knockouts survive at 75%, 24 litters (mean 160 pups): A chi-square 1:2:1 22.6%; C binomial knockouts vs 1/4 27.9%; D knockouts vs wild-type 20.0%
Knockouts survive at 75%, 48 litters (mean 321 pups): A chi-square 1:2:1 43.8%; C binomial knockouts vs 1/4 54.7%; D knockouts vs wild-type 38.3%
Knockouts survive at 50%, 6 litters (mean 37 pups): A chi-square 1:2:1 24.1%; C binomial knockouts vs 1/4 28.9%; D knockouts vs wild-type 20.0%
Knockouts survive at 50%, 12 litters (mean 75 pups): A chi-square 1:2:1 48.5%; C binomial knockouts vs 1/4 57.3%; D knockouts vs wild-type 40.1%
Knockouts survive at 50%, 24 litters (mean 149 pups): A chi-square 1:2:1 83.1%; C binomial knockouts vs 1/4 89.3%; D knockouts vs wild-type 73.9%
Knockouts survive at 50%, 48 litters (mean 299 pups): A chi-square 1:2:1 99.0%; C binomial knockouts vs 1/4 99.8%; D knockouts vs wild-type 96.5%
No lethality, 2 litters (mean 14 pups): A chi-square 1:2:1 4.0%; B exact multinomial 4.2%; C binomial knockouts vs 1/4 3.6%; D knockouts vs wild-type 1.6%