False-positive rate with no true difference (8 per group, 100,000 experiments, seed 20261110): two_sided 0.0477 one_sided_direction_fixed_in_advance 0.0484 switch_to_one_sided_if_it_helps 0.0968 one_sided_planned_but_wrong_direction_also_reported 0.0718 one_sided_at_0.025 0.0242 Animals per group, two-sample Student t-test, alpha 0.05: power 0.80 d 0.5: two-sided 64 one-sided 51 saving 20.3% power 0.80 d 0.8: two-sided 26 one-sided 21 saving 19.2% power 0.80 d 1.0: two-sided 17 one-sided 14 saving 17.6% power 0.80 d 1.5: two-sided 9 one-sided 7 saving 22.2% power 0.80 d 2.0: two-sided 6 one-sided 4 saving 33.3% power 0.90 d 0.5: two-sided 86 one-sided 70 saving 18.6% power 0.90 d 0.8: two-sided 34 one-sided 28 saving 17.6% power 0.90 d 1.0: two-sided 23 one-sided 18 saving 21.7% power 0.90 d 1.5: two-sided 11 one-sided 9 saving 18.2% power 0.90 d 2.0: two-sided 7 one-sided 6 saving 14.3%