Batch 1: geometric mean area control 44,405 um2, drug 37,892 um2 (ratio 0.85)
Batch 2: geometric mean area control 40,955 um2, drug 35,587 um2 (ratio 0.87)
Batch 3: geometric mean area control 44,282 um2, drug 50,151 um2 (ratio 1.13)
Batch 4: geometric mean area control 41,585 um2, drug 35,601 um2 (ratio 0.86)
Organoids measured: 484 (8 to 30 per well)
A. Organoids as n (239 vs 245), Welch t-test on log area: drug / control 0.90, p = 0.054
B. Wells as n (12 vs 12), Welch t-test on log area: drug / control 0.92, p = 0.17
C. Batches as n, log ratio per batch (paired, n = 4): drug / control 0.92 (95% CI 0.74 to 1.15), p = 0.32