No drug effect: p<0.05 with A organoids as n 22.7%; B wells as n 2.1%; C batches as n, paired 4.6%; average estimated ratio 1.004 with all organoids, 1.002 after excluding organoids below 15,000 um2 (on average 16.9 control and 16.9 drug organoids excluded per study)
Drug makes organoids 20% smaller: p<0.05 with A organoids as n 87.0%; B wells as n 43.3%; C batches as n, paired 36.7%; average estimated ratio 0.804 with all organoids, 0.849 after excluding organoids below 15,000 um2 (on average 16.9 control and 30.4 drug organoids excluded per study)
Drug makes organoids 20% smaller, 8 batches: p<0.05 with A organoids as n 97.3%; B wells as n 73.6%; C batches as n, paired 81.4%; average estimated ratio 0.803 with all organoids, 0.849 after excluding organoids below 15,000 um2 (on average 34.0 control and 61.3 drug organoids excluded per study)