Missing values: 20.2% of all values; proteins with any missing value: 472 of 1000 Impute each sample's minimum: 1000 proteins tested; 46 called (q < 0.05), 0 of them unchanged (false discovery proportion 0.0%); 46 of the 100 changed proteins found Impute a down-shifted value (sample mean - 1.8 SD): 1000 proteins tested; 54 called (q < 0.05), 0 of them unchanged (false discovery proportion 0.0%); 54 of the 100 changed proteins found Keep proteins with at least 3 valid values per group, no imputation: 773 proteins tested; 66 called (q < 0.05), 1 of them unchanged (false discovery proportion 1.5%); 65 of the 100 changed proteins found