Group means (vehicle, 1, 3, 10 mg/kg): 99.12, 100.85, 94.87, 94.52 Dunnett, each dose vs vehicle: p = 0.69, 0.09, 0.07 Linear trend contrast: estimate = -19.78, t = -3.27, df = 20, p = 0.0038 Change per dose step (scores 0-3): -1.98 (95% CI -3.24 to -0.72)